Characteristics of enantioseparation of novel chiral sulfoxides using polysaccharide based chiral stationary phases containing methyl group

Author: natia shashviashvili
Co-authors: Mari-luiza konjaria
Keywords: Chiral sulfoxide, mobile phase, chiral selector
Annotation:

The goal of the present research was to screen newly synthesized chiral sulfoxides on their chiral recognition ability with 16 different cellulose phenylcarbamate-based chiral selectors in high-performance liquid chromatography. Most of these 16 chiral selectors were non-commercial products and synthesized in the frame of the present project. By systematic variation of the chemistry and structure of chiral selectors and selectands those structural features were prevailed which are most critical for selector-selectand binding and chiral recognition ability. In this work only columns with methyl- and chloro-methyl-substituted-phenylcarbamates are discussed. Our experiment was performed using high-performance liquid chromatograph (HPLC). Following mobile phases were used: methanol, ethanol, 2-propanol and the mixture of n-hexane and 2-propanol.