Influence of Saperavi flavonoids on the kainic acid-induced epilepsy model

Author: natia adamashvili
Keywords: saperavi, flavonoids, kainic acid, epilepsy, hippocampus
Annotation:

The aim of the research was in behavioral experiments (open field and T- maze labyrinth) investigation the effects of early postnatal (P7-P15 period) administration of active fraction of flavonoids from Saperavi on behavior changes induced by kainic acid-status epilepticus; to compare the antiepileptic and neuroprotective capabilities of Saperavi flavonoids with effects of classic flavonoid-Resveratrol. In the electrophysiological experiments we evaluated the nutritional effects of Saperavi flavonoids on neuronal activity of CA1-field of adult rat’s hippocampus. There were three groups of animals used in experiments: I-Control Group, which in postnatal P7-P15 period was administered a placebo; II- experimental group, which was fed with Saperavi flavonoids (25mg/kg) during the P7-P15 period; III- experimental group – at postnatal days P7 –P15 was subjected with Resveratrol (daily dose was - 25mg/kg). It was shown that early postnatal feeding of rats with Saperavi flavonoids causes redaction of mortality induced by the kainic acid-status epilepticus, also causes decrease of the number and duration of the behavioral seizures, which was in correlation with correction of memory disturbance induced by epilepsy. To compare the effects of Saperavi flavonoids with those of Resveratrol revealed that anticonvulsant/antiamnesic potency of Saperavi flavonoids were much more strength. Electrophysiological experiments revealed that in Saperavi flavonoides administered rats the duration and amplitude of epileptiform discharges induced by intrahippocampal high frequency electrical stimulation were decreased.

Lecture files:

საფერავის ფლავონოიდების გავლენა კაინის მჟავით განპირობებულ ეპილეფსიის მოდელზე [ka]