synthesis and study of [4-(imidazole-1-yl)thiazole-2-yl)]naphthylamines

Author: Eka Gogaladze
Keywords: thiazole, naphtalene, imidazole
Annotation:

New diheterocyclic thiazole containing system, [4-(imidazol-1-yl)thiazole-2-yl)]naphtylamine, was synthesized by 4 steps. Firstly, synthesis of 1-naphtalylthiourea was carried out by using two different methods to establish optimal conditions. Cyclisation of synthesized thiourea was realized by using ethylbromoacetate in ethanol. The favorable conditions (increasing of yield) was chosen for desoxychlorynation of 2-(naphtalen-1-ylamino)thiazole-4(5H)-one. The target product was obtained by condensation of 4-chloro-N(naphtalen-1-yl)thiazol-2-amine and benzimidazole in DMF.